Looking at Dupixent (Dupilumab)

"Brought to you by Sanofi and Regeneron"

A friend asked me to look at his Dupixent. An injectable medication that he had been taking for his severe eczema. Fortunately he no longer requires it. He was paying Au$6 for 2 injections given fortnightly. Although the cost to the Australian Government accoring to the label was ~$1800.

Advertising on Dupixent can be found here: https://www.dupixent.com/atopicdermatitis/

The FDA data “snapshot” here:

https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-dupixent

In the future I think I will refer to this as infoganda for obvious reasons.

Here is a link to the NEJM study (which was not linked to by either the pharmaceutical or FDA sites):

https://www.nejm.org/doi/full/10.1056/NEJMoa1804093

I note that the study was paid for by Sanofi and Regeneron and that the data was collected by the investigators and analysed by the sponsors (i.e. them) and according to the International Conference of Harmonisation which I note is overseen by the WHO so clearly legit and nothing to see here.

I started looking at the Covid-19 vaccinations 12 months ago and now I have looked at injectable medications and salt. I am reminded about a quote that I have shared previously “For every mistake made by not doing; 10 are made by not looking”

I do not have any ability to do any analysis more sophisticated than pH, temperature and background EMF. However I got reasonably proficient at looking and taking photos…

So what do I look for?

Stuff that looks unusual. Pretty simple really and I leave it up to others to tell me what I am seeing is “normal” or not. The most significant response I have had is …. crickets…

Anyway that’s fine I have seen enough weird shyte in the last 12 months that I think that what I am doing is a valid pursuit. If you agree and would like to discuss further consider subscribing please and joining one of the weekly meetings. So I can do more of this … :-)

My process has been to observe a small drop of sample at a low magnification and watch how it dries. I repeat with a larger drop. Then I observe a small drop under a coverslip and up to and above 1000x magnification. Then it is always interesting to go back and have another look some days later.

This is Dupixent. top of the drop 40x, middle of the drop 40x,100x,200x respectively

the full video is on my website here: https://drdavidnixon.com//1/en/topic/dupixent

At 13:50 we can see the dots moving in a stream as the drop dries out. video showing all those small dots moving… very similar to the long acting insulin actually… just saying….

and here is the dried drop

which looks similar to some of the drops of dried blood that I took a couple of months ago - this may be expected but maybe not…

this is how the initial drop looked:

As the edges of the drop receded under the coverslip material was accumulated next to the edge of the drop and some interesting structures were seen:

the dots were never far away:

My favourite at the end:

So in summary, small particles visible both with and without coverslip which appear the same as those seen in the long acting insulin made by or in association with the same company. Produces interesting pattern on drying without coverslip which is probably not significant but who knows? Produces even more interesting pattern on partially drying under the coverslip which I suspect is significant…

Have a great end to the week!

David